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We only have synthetic 5-meo dmt freebase due to the increasing demand.


It’s difficult to imagine a psychedelic more potent than DMT (dimethyltryptamine) — particularly 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine or O-methyl-bufotenin).

This compound is a tryptamine-based psychedelic, which means it mimics neurotransmitters like serotonin to exert most of its psychedelic effects.

5-MeO-DMT is naturally-occurring — most predominantly found in a species of toad called Bufo alvarius (AKA the Colorado River Toad or the Sonoran Desert Toad). It’s also common in synthetic form, where it can be smoked, vaped, or insufflated (snorted).

This psychedelic is notoriously fast-acting, but the effects are very short-lived.

A quick rip of 5-MeO-DMT can take you into a timeless hyperspace where users often report chatting with machine elves. While the experience can feel like a lifetime, most users return to reality within 45 minutes.

Regardless of how short, a trip on 5-MeO-DMT can seriously shift your perspective.

Wonderful, terrifying, and sometimes healing, 5-MeO’s potency is an enigma that can humble and inspire.


  • Level of Risk: Low
  • Most Common Side Effects: Ego-dissolution, Ineffable
  • Duration of Effects: Peak 10–30 min, 1-hour total

What’s the Difference Between N,N-DMT & 5-MeO-DMT?

Before going much deeper, let’s be clear — there are several different DMT analogs, each unique from the last.

“DMT” usually refers to N,N-DMT, the active psychedelic ingredient in ayahuasca and changa.

Structurally, N,N,DMT and 5-MeO-DMT are only differentiated by adding an oxygen molecule to its Indole ring.

While some effects of 5-MeO and N,N,DMT are comparable — i.e., rapid onset and super intense psychedelic experience — the 5-MeO experience transcends the wild, geometric visuals of N,N-DMT.

The effects of 5-MeO are often conveyed as “oneness,” “non-dual,” or “ineffable.” Ultimately, words can not capture the significance of what 5-MeO can open us up to. Most users will agree that 5-MeO-DMT pushes the user even further between worlds than N,N,DMT.

What’s The Dose of 5-MeO-DMT?

The effective dose of 5-MeO-DMT depends on the delivery method — smoked, vaped, snorted, swallowed, injected, or taken rectally.

The form also matters — toad venom, synthetic, snuff, or oral preparation.

Administration of snuffs sourced from the Amazon should be done by a trained practitioner, as dosage can vary depending on the specific plants and preparation method used.

In Tryptamine Palace, James Oroc notes that finding an optimal dose when smoking is best adjusted in 2 mg increments. He also explains that finding your “minimum effective dose” helps you actually remember the transcendental experience. This is because it is easy to smoke too much, get stuck in a “white hole,” and have no recollection of what happened.

1. Bufo Toad Venom Dosage

The standard dose range for raw Bufo alvarius toad venom is between 10 and 60 mg, smoked or vaped.

Bufo toad venom alkaloid concentration varies. Alexander Shulgin reported in TiHKAL that the venom could contain up to 15% 5-MeO-DMT.

Other sources mention a range of 10-30%. In short, potency is highly variable, and individual responses to bufo will vary greatly. Always start small, work your way up, and find an experienced practitioner when working with toad venom.

2. Synthetic 5-MeO-DMT Dose

Synthetic 5-MeO is often smoked but is also sometimes snorted, boofed, and taken orally or sublingually. Smoking will come on fast and end quickly. Snorting, plugging, and oral routes have a gentler, slower come-up and will last longer.

When deciding which access route to take, consider if the substance is HCl or freebase. Most favor HCl for snorting and freebase for smoking. Snorting will burn (freebase a lot), and online reports suggest rectal might too. Both methods are known to cause nausea.


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